Ketosis-Prone Diabetes (KPD): case report
نویسندگان
چکیده
Background The ketosis-prone diabetes syndrome (KPD) is characterized by a severe dysfunction of pancreatic beta cells, leading to the diagnosis of diabetic ketoacidosis (DKA) in patients that do not present the typical phenotype of diabetes mellitus type 1 (DM1). This heterogenic condition has been observed more often in urgent care facilities, leading to confusion in diagnosis and potential treatment errors, with negative outcomes. KPD must be suspected in patients with clinical presentation and laboratory findings of diabetic ketoacidosis that do not fit the clinical and laboratorial profiles of DM1. The incidence rate of KPD is highest in African-Americans and Hispanics, and obesity is the most common phenotype. Overall, patients have type 2 diabetes mellitus (DM2) with considerable family history. Four subgroups were identified for KPD: presence or absence of autoimmune response against beta cells (A+ or A-) and presence or absence of pancreatic reserve (B+ or B-).
منابع مشابه
Syndromes of ketosis-prone diabetes mellitus.
Ketosis-prone diabetes (KPD) is a widespread, emerging, heterogeneous syndrome characterized by patients who present with diabetic ketoacidosis or unprovoked ketosis but do not necessarily have the typical phenotype of autoimmune type 1 diabetes. Multiple, severe forms of beta-cell dysfunction appear to underlie the pathophysiology of KPD. Until recently, the syndrome has lacked an accurate, cl...
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Ketone-prone diabetes (KPD) is considered one of the atypical diabetes syndromes because its presentation can lead to misdiagnosis of the type of diabetes. Patients with KPD present in diabetic ketoacidosis (DKA), but once the DKA resolves, some patients can discontinue insulin and maintain adequate glycemic control with oral agents (1). Here, we present the case of a patient who was diagnosed ...
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SUMMARY We describe three patients presenting with diabetic ketoacidosis secondary to ketosis prone type 2, rather than type 1 diabetes. All patients were treated according to a standard DKA protocol, but were subsequently able to come off insulin therapy while maintaining good glycaemic control. Ketosis-prone type 2 diabetes (KPD) presenting with DKA has not been described previously in Irish ...
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